Lab ResearchersAnagh Pathak
Kirti Saluja Samuel Berkins Representative PublicationsNeuromolecular interactions guiding homeostatic mechanisms underlying healthy ageing: A view from computational microscope (bioRxiv)
Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan (Communications Biology, 2022) How synchrony and metastable network dynamics are affected in fast and slow timescales with aging: Implication for Cognition (bioRxiv) Lifespan associated global patterns of coherent neural communication. (NeuroImage, 2020) Metastability of Cortical BOLD Signals in Maturation and Senescence (IEEE Conference proceedings IJCNN, 2017) Metastability in Senescence (Trends in Cognitive Sciences, 2017) |
The first thing that comes to mind when we hear aging is "graying of hair" but aging is much more than that. Healthy aging is associated with structural changes in many regions of the brain and functional decline in various cognitive domains.
Aging changes the intrinsic properties of neural oscillations, both in resting state and in the context of cognitive tasks. How the spatiotemporal organization of the neuronal rhythms changes in the process of aging? Is there any effect of thalamus in the context of healthy aging? Our lab aims to characterize the dynamic repertoire of neural oscillations by adopting methodologies like source localization, signal processing at both sensor and source level. We also employ measures like amplitude envelope correlations, weighted phase lag index and global coherence to characterize the frequency-based functional connectivity. Our recent study found a consistent increase in the power of beta oscillations and a decrease in the peak alpha frequency as a function of age. We have also established that within network casual connections become progressively weaker with age, between network casual connections are getting stronger with age among core neurocognitive networks. Secondly, significant modifications were found in causal connections and net causal outflows in the presence of thalamus. (On the right) Figure taken from Pathak, Anagh, et al. 2022, the results indicate that phase locking is preserved at the Subject Specific Alpha band while the Peak Alpha Frequency slows with age. Our lab is also interested in understanding how the brain network interaction and reconfiguration contributes to behavioral traits in Autism Spectrum Disorder. |